Stop scaling up your fermentation process in the dark. Let Torch light the way.
Enter your lab-scale process parameters and get a comprehensive MOSCH report that qualitatively and quantitatively shows you how risky it is to scale-up your process from lab → pilot → industry.
The MOSCH report · A new standard for fermentation scale-up
Five critical questions. One structured report.
Mixing
Is mixing fast enough to dissipate gradients?
Scored based on the ratio of the required mixing timescale to the mixing time.
Oxygen Transfer
Can the reactor deliver sufficient oxygen to the cells at scale?
Scored based on the ratio of the oxygen transfer rate (OTR) to the oxygen uptake rate (OUR) of the microbe.
Shear Stress
Is impeller tip speed causing shear damage to cells?
Scored based on the ratio of shear tolerance of the microbe to the shear due to the impeller.
CO₂ Accumulation
Is dissolved CO₂ accumulating at toxic levels?
Scored based on the ratio of the CO₂ toxicity threshold of the microbe to the CO₂ present in the reactor.
Heat Transfer
Can the reactor withdraw the heat generated at scale?
Scored based on the ratio of the heat removal capacity of the reactor to the metabolic heat generated during the culture.
A decision-support layer, not a black box.
The MOSCH report projects a dimensionless risk score at both lab and target scale. So you can see where scale-up assumptions diverge before committing to any infrastructure investment. Lower scores indicate higher risk. Risk categories are reported as Low, Moderate, High, and Critical. Treat it like getting a second opinion on the most critical parameters that define the success of your process.
Frequently Asked Questions
Your report is built using a combination of kinetics, thermodynamics, transport phenomena, metabolism, and uncertainty quantification. Together, these produce risk scores across all categories based on the inputs you provide.